Jamie Lee Curtis wins first Oscar for All at Once.

Everything Everywhere All At Once got off to a flying start at the Oscars with Jamie Lee Curtis and Ke Huy Quan taking home major awards.

The sci-fi epic, directed by Daniel Kwan and Daniel Scheinert, entered the night with 11 nominations after winning top prizes at other US awards shows this year.

An emotional Curtis paid tribute to all the special people in her life and exclaimed, “We just won an Oscar” after receiving the gong for best supporting actress — her first Oscar.

Ke Huy Quan accepts the award for Best Performance by an Actor in a Supporting Role (AP/Chris Pizzello)

The US actress, 64, said on stage: “I know it looks like I’m standing here alone, but I’m not. There are hundreds of people and hundreds of people. We just won an Oscar.

“To my family, my beautiful husband Christopher Guest, my daughters Annie and Ruby, my sister Kelly – we just won an Oscar.

“To all the people who have supported the genre films I’ve made for hundreds and thousands, we just won an Oscar together.”

Looking skyward, the actress – born into Hollywood royalty through parents Janet Leigh and Tony Curtis – added: “And my mum and dad were both nominated for Oscars in different categories, I just won an Oscar. “

Quan received a standing ovation as he took the stage and cheered “The American Dream” after winning the Best Supporting Actor award.

“My mother is 84 years old and watches at home. Ma, I just won an Oscar!” he said.

He continued: “My journey began on a boat. I spent a year in a refugee camp and somehow ended up here on the biggest stage in Hollywood.

“They say stories like this only come out in the cinema. I can’t believe this is happening to me – this is the American Dream.

“Thank you to the Academy for the honor of her life.”

95th Academy Awards - Show

Guillermo del Toro accepts the award for Best Animated Feature (AP/Chris Pizzello)

Quan has stormed this year’s awards season, earning Best Support awards at nearly every major ceremony.

The first Oscar of the night, animated feature film, went to Pinocchio by Guillermo del Toro.

On stage, the Mexican filmmaker said, “Animation is cinema, animation is not a genre and animation is ready to take the next step.”

Host Jimmy Kimmel opened the night by taking to the stage, which was attached to a parachute in a nod to best picture nominee, Top Gun: Maverick.

“Give me a second, I need to adjust my danger zone. My banshees are trapped in my inisherin right now,” he said.

“I know it’s a dream for some people to be here, thanks for inviting me.”

He also referenced last year’s slap in the face and praised the Irish talent nominated at this year’s ceremony.

“Five Irish actors have been nominated tonight which meant the chances of another fight on stage have greatly increased,” he said.

The remark elicited laughter from the audience and cast of The Banshees Of Inisherin.

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